| WORK ADDRESS: |
Southeast Radiation Oncology 200 Queens Rd, Ste 400 Charlotte, NC 28204
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| EDUCATION/ TRAINING |
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| 2002-2003 |
Chief Resident, Radiation Oncology Massachusetts General Hospital, Harvard Medical School Boston, MA
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| 2000-2004 |
Resident, Radiation Oncology Massachusetts General Hospital, Harvard Medical School Boston, MA
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| 1999-2000 |
Preliminary Internship, Internal Medicine University of Hawaii, Honolulu, HI
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| 1994-1999 |
Doctor of Medicine with Honors University of North Carolina, Chapel Hill, NC
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| 1990-1994 |
Bachelor of Science with Distinction University of North Carolina, Chapel Hill, NC
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| CERTIFICATION |
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| 2004 |
American Board of Radiology, Board Certified
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| 2004-Present |
North Carolina Medical License
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| 2004-Present |
South Carolina Medical License
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| 2004 |
Texas State Medical License
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| 2002-2004 |
Masschusetts Medical License
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| 2000-2002 |
Training Medical License, Commonwealth of Massachusetts
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| 1999-2000 |
Training Medical License, State of Hawaii
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| HONORS AND AWARDS |
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| 2004 |
Radiation Therapy Oncology Group Resident Travel Award for RTOG Semi-Annual Meeting
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| 2003 |
American College of Radiation Oncology Howard W. Wong Scholarship
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| 2001 |
ASCO/AACR Fellow for the Molecular Oncology in Clinical Oncology Workshop in Aspen, CO
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| 2001 |
ASCO/AACR Fellow for Methods in Clinical Cancer Research Workshop in Vail, CO
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| 1999 |
Isaac Hall Manning Award Award honoring a senior class medical student for "outstanding scholarship, character, leadership, initiative, and investigative research"
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| 1998 |
Judith Joklik Cancer Research Award Award honoring an outstanding contribution in cancer research by a medical student at the University of North Carolina at Chapel Hill.
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| 1998 |
Alpha Omega Alpha Medical Honor Society
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| 1997-1998 |
Howard Hughes Medical Institute-National Institutes of Health Research Scholar at the Cloister Provides recipients funding and a stipend for a year of in-depth research on the topic of their choice on the campus of the NIH.
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| 1997-1998 |
Selected for The Distinguished Medical Scholars Program at The University of North Carolina School of Medicine
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| 1995 |
Medical Foundation Co-Founder's Student Research Award Awarded to students performing research deemed to be of high quality and worth. I received one of four monetary awards granted, for my investigations of the role of Fas in radiation induced apoptosis.
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| RESEARCH EXPERIENCE |
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| 2001-Present |
Bladder Motion During External Beam Radiation Therapy. Supervisor: William U. Shipley, MD. Authored a DFCI IRB approved protocol to examine bladder motion using the BAT ultrasound in patients with bladder cancer being treated with external beam irradiation.
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| 2002-Present |
Prognostic Significance of Modifiable Bio-Markers in Esophageal Cancer Patients Treated with Multi-Modality Therapy. Supervisor: Christopher G. Willett, MD. Created tissue arrays to examine multiple modifiable biomarkers for prognostic significance in esophageal cancer patients treated with multi-modality therapy.
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| 2003-Present |
Role of Taxol in Trimodality Therapy for Esophageal Cancer. Supervisor: Noah C. Choi, MD. Authored IRB approved protocol allowing us to examine the outcomes of patients treated with Neoadjuvant Cisplatin, 5-FU, Taxol and Radiation versus Neoadjuvant Cisplatin, 5-FU and Radiation.
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| 2001-2003 |
Radiation Dose Escalation in Limited-Stage Small-Cell Lung Cancer. Supervisor: Noah C. Choi, MD. Authored IRB approved protocol, which allowed us to examine the role of radiation dose escalation in limited-stage small-cell lung cancer.
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| 1997-1998 |
Novel Approaches to Purging of Cancer Cells from Autologous Stem Cell Harvests. Supervisor: Kenneth Cowan MD, PhD. Developed novel adenoviral vectors in an effort to purge breast carcinoma cells from autologous stem cell harvests.
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| 1995 |
Role of Fas in Gamma Irradiation Induced Apoptosis. Supervisor: Philip Cohen, MD. Demonstrated that defects in Fas in lpr mice resulted in radioresistance suggesting a potential role of Fas in radiation-induced apoptosis.
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| GRANTS |
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| 2003 |
Radiation Therapy Oncology Group Seed Grant Prognostic significance of modifiable biomarkers in esophageal cancer patients treated with multi-modality therapy.
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| PEER REVIEWED PUBLICATIONS |
Roof KS, Coen J, Lynch TJ et al. Concurrent Cisplatin, 5-FU, Pachtaxcl and Radiation Therapy in Patients with Locally Advanced Esophageal Cancer. Int J Radiat Oncol Biol Phys. 2006 July 15; 65(4):1120-8.
Roof KS, Fidias P, Lynch TJ, Ancukiewicz M, Choi NC: Radiation Dose Escalation in Limited-Stage Small-Cell Lung Cancer. Int. J. Radiation Oncology Biol. Phys. 2003; 57:701-708.
Roof KS, Fidias P, Lynch TJ, Choi NC. Radiation Dose Intensification in Limited-Stage Small-Cell Lung Cancer. Clinical Lung Cancer 2003; 4:339-346
Reap EA, Roof K, Maynor K, Borrero M, Booker J, and Cohen PL: Radiation and Stress-Induced Apoptosis: A Role for Fas / Fas Ligand Interactions. Proceedings of the National Academy of Science. 1997; 94: 5750-5755.
Reap EA, Roof K, Maynor K, and Cohen PL: Markedly Diminished Radiation-induced Lymphocyte Apoptosis in lpr Mice Suggests a Role for Fas in Eliminating Damaged Cells. Annals of the New York Academy of Sciences. 1997; 815:116-118.
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| PRESENTATIONS |
Roof K, A Mazal, S Sarkar, J Leong, AL Zietman, G.T.Y. Chen, WU Shipley. Inter-fraction bladder motion during radical radiotherapy treatment of muscle invading bladder cancer: An analysis of serial CT images and CT-BAT data to better define appropriate PTV expansion beyond the bladder. Poster Presentation at the ASTRO Annual Conference in Atlanta, GA 10/2004
Roof K, Coen J, Lynch TJ, Wright C, Fidias P, Willett CG, Choi NC. Neo-adjuvant radiation, cisplatin, 5-FU +/- paclitaxel in locally advanced esophageal cancer. Poster presentation at the 2004 ASCO Annual Conference in New Orleans, LA 6/2004.
Roof K, Ancukwiecz M, Fidias P, Lynch T, Choi, NC: Radiation Dose Escalation in Limited Stage Small Cell Lung Cancer. Poster presentation at the 2002 ASCO Annual Conference in Orlando, FL 5/2002.
Roof K and Cowan K. Purging of Breast Cancer Cell Contaminants from Autologous Stem Cell Harvests: A Novel Gene Therapy Based Approach. Platform presentation at Howard Hughes Medical Institute-National Institutes of Health Research Scholars' Science Symposium in Bethesda, MD 5/19-21/98.
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| PROFESSIONAL ASSOCIATIONS |
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| 2000-Present |
American Society of Therapeutic Radiology and Oncology
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| 2002-Present |
American Society of Clinical Oncology
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| 1994-Present |
American Medical Association
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| 2003-Present |
American Medical Association
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| 2000-2004 |
Massachusetts Radiological Society, Member
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