Kevin S. Roof, M.D.

Southeast Radiation Oncology
200 Queens Rd, Ste 400
Charlotte, NC 28204

Chief Resident, Radiation Oncology
Massachusetts General Hospital, Harvard Medical School Boston, MA

Resident, Radiation Oncology
Massachusetts General Hospital, Harvard Medical School Boston, MA

Preliminary Internship, Internal Medicine
University of Hawaii, Honolulu, HI

Doctor of Medicine with Honors
University of North Carolina, Chapel Hill, NC

Bachelor of Science with Distinction
University of North Carolina, Chapel Hill, NC

American Board of Radiology, Board Certified

North Carolina Medical License

South Carolina Medical License

Texas State Medical License

Masschusetts Medical License

Training Medical License, Commonwealth of Massachusetts

Training Medical License, State of Hawaii

Radiation Therapy Oncology Group Resident Travel Award for RTOG Semi-Annual Meeting

American College of Radiation Oncology Howard W. Wong Scholarship

ASCO/AACR Fellow for the Molecular Oncology in Clinical Oncology Workshop in Aspen, CO

ASCO/AACR Fellow for Methods in Clinical Cancer Research Workshop in Vail, CO

Isaac Hall Manning Award
Award honoring a senior class medical student for "outstanding scholarship, character, leadership, initiative, and investigative research"

Judith Joklik Cancer Research Award
Award honoring an outstanding contribution in cancer research by a medical student at the University of North Carolina at Chapel Hill.

Alpha Omega Alpha Medical Honor Society

Howard Hughes Medical Institute-National Institutes of Health Research Scholar at the Cloister
Provides recipients funding and a stipend for a year of in-depth research on the topic of their choice on the campus of the NIH.

Selected for The Distinguished Medical Scholars Program at The University of North Carolina School of Medicine

Medical Foundation Co-Founder's Student Research Award
Awarded to students performing research deemed to be of high quality and worth. I received one of four monetary awards granted, for my investigations of the role of Fas in radiation induced apoptosis.

Bladder Motion During External Beam Radiation Therapy. Supervisor: William U. Shipley, MD. Authored a DFCI IRB approved protocol to examine bladder motion using the BAT ultrasound in patients with bladder cancer being treated with external beam irradiation.

Prognostic Significance of Modifiable Bio-Markers in Esophageal Cancer Patients Treated with Multi-Modality Therapy. Supervisor: Christopher G. Willett, MD. Created tissue arrays to examine multiple modifiable biomarkers for prognostic significance in esophageal cancer patients treated with multi-modality therapy.

Role of Taxol in Trimodality Therapy for Esophageal Cancer. Supervisor: Noah C. Choi, MD. Authored IRB approved protocol allowing us to examine the outcomes of patients treated with Neoadjuvant Cisplatin, 5-FU, Taxol and Radiation versus Neoadjuvant Cisplatin, 5-FU and Radiation.

Radiation Dose Escalation in Limited-Stage Small-Cell Lung Cancer. Supervisor: Noah C. Choi, MD. Authored IRB approved protocol, which allowed us to examine the role of radiation dose escalation in limited-stage small-cell lung cancer.

Novel Approaches to Purging of Cancer Cells from Autologous Stem Cell Harvests. Supervisor: Kenneth Cowan MD, PhD. Developed novel adenoviral vectors in an effort to purge breast carcinoma cells from autologous stem cell harvests.

Role of Fas in Gamma Irradiation Induced Apoptosis. Supervisor: Philip Cohen, MD. Demonstrated that defects in Fas in lpr mice resulted in radioresistance suggesting a potential role of Fas in radiation-induced apoptosis.

Radiation Therapy Oncology Group Seed Grant
Prognostic significance of modifiable biomarkers in esophageal cancer patients treated with multi-modality therapy.

Roof KS, Coen J, Lynch TJ et al. Concurrent Cisplatin, 5-FU, Pachtaxcl and Radiation Therapy in Patients with Locally Advanced Esophageal Cancer. Int J Radiat Oncol Biol Phys. 2006 July 15; 65(4):1120-8.

Roof KS, Fidias P, Lynch TJ, Ancukiewicz M, Choi NC: Radiation Dose Escalation in Limited-Stage Small-Cell Lung Cancer. Int. J. Radiation Oncology Biol. Phys. 2003; 57:701-708.

Roof KS, Fidias P, Lynch TJ, Choi NC. Radiation Dose Intensification in Limited-Stage Small-Cell Lung Cancer. Clinical Lung Cancer 2003; 4:339-346

Reap EA, Roof K, Maynor K, Borrero M, Booker J, and Cohen PL: Radiation and Stress-Induced Apoptosis: A Role for Fas / Fas Ligand Interactions. Proceedings of the National Academy of Science. 1997; 94: 5750-5755.

Reap EA, Roof K, Maynor K, and Cohen PL: Markedly Diminished Radiation-induced Lymphocyte Apoptosis in lpr Mice Suggests a Role for Fas in Eliminating Damaged Cells. Annals of the New York Academy of Sciences. 1997; 815:116-118.

Roof K, A Mazal, S Sarkar, J Leong, AL Zietman, G.T.Y. Chen, WU Shipley. Inter-fraction bladder motion during radical radiotherapy treatment of muscle invading bladder cancer: An analysis of serial CT images and CT-BAT data to better define appropriate PTV expansion beyond the bladder. Poster Presentation at the ASTRO Annual Conference in Atlanta, GA 10/2004

Roof K, Coen J, Lynch TJ, Wright C, Fidias P, Willett CG, Choi NC. Neo-adjuvant radiation, cisplatin, 5-FU +/- paclitaxel in locally advanced esophageal cancer. Poster presentation at the 2004 ASCO Annual Conference in New Orleans, LA 6/2004.

Roof K, Ancukwiecz M, Fidias P, Lynch T, Choi, NC: Radiation Dose Escalation in Limited Stage Small Cell Lung Cancer. Poster presentation at the 2002 ASCO Annual Conference in Orlando, FL 5/2002.

Roof K and Cowan K. Purging of Breast Cancer Cell Contaminants from Autologous Stem Cell Harvests: A Novel Gene Therapy Based Approach. Platform presentation at Howard Hughes Medical Institute-National Institutes of Health Research Scholars' Science Symposium in Bethesda, MD 5/19-21/98.

American Society of Therapeutic Radiology and Oncology

American Society of Clinical Oncology

American Medical Association

American Medical Association

Massachusetts Radiological Society, Member